Find and compare 4 Star hotels in South San Francisco
Wander Wisely with exceptional service, 24/7 support
Save an extra 10% or more on select hotels with Member Discounts
Access exclusive hotel deals, only with the Travelocity app
Check prices for these dates
Featured South San Francisco 4 Star hotels

Hotel Riu Plaza Fisherman's Wharf
Room was small and very outdated definitely not worth the 400+ a night price
Reviewed on Mar 12, 2026

DoubleTree by Hilton Hotel Berkeley Marina
This was great
Reviewed on Mar 13, 2026

Grand Hyatt at SFO
Convenient
Reviewed on Mar 13, 2026

DoubleTree by Hilton San Francisco Airport
friendly stuff
Reviewed on Mar 13, 2026

Hilton San Francisco Financial District
Clean room and friendly staff
Reviewed on Mar 13, 2026

Club Quarters Hotel in San Francisco
Great location. Near the waterfront and North Beach (you can walk to everything. Unfortunately, my room needed a reno. The carpet, shower head and office chair need to go. I also don't think it was cleaned very well.
Reviewed on Mar 12, 2026

Hyatt Regency San Francisco
Everything in walking distance.. Valet was amazing.. Comfortable
Reviewed on Mar 13, 2026

Oakland Marriott City Center
Comfortable and clean
Reviewed on Mar 11, 2026

Grand Hyatt San Francisco
The location and hotel itself were great. Check in was a breeze and we appreciated the waters we were given. We had alot of fun. Unfortunately the next day when we got our car back from the valet someone had stolen both our sunglasses from the center console. We know SF is notorious for car break ...
Reviewed on Mar 11, 2026

Hotel Zoe Fisherman's Wharf
Great hotel. Very clean. Loved the modern/rugged style decor.
Reviewed on Mar 12, 2026
4 Star Hotels South San Francisco
Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?
Come on, you deserve it!
The best part about staying in South San Francisco 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.
Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.
The best four star hotels in South San Francisco will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!
If you’re looking for 4 star hotels in South San Francisco, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.
Recent South San Francisco hotel reviews by fellow wanderers

Travelodge by Wyndham San Francisco Airport North
More ways to wander South San Francisco
Explore More Ways to Travel with Travelocity
- 3 Star Hotels in Berkeley
- 3 Star Hotels in Palo Alto
- 3 Star Hotels in Redwood City
- 3 Star Hotels in Santa Clara
- 3 Star Hotels in Sausalito
- 4 Star Hotels in San Francisco
- 4 Star Hotels in Vallejo
- 5 Star Hotels in Fremont
- 5 Star Hotels in Half Moon Bay
- 5 Star Hotels in Hayward
- 5 Star Hotels in Mountain View
- 5 Star Hotels in Palo Alto
- 5 Star Hotels in San Mateo
- 5 Star Hotels in Santa Clara
- 5 Star Hotels in Sausalito
- 5 Star Hotels in Sunnyvale
- B&B in Brisbane
- Brisbane Hotels
- San Bruno Hotels
- Hotels near San Francisco Intl.
- Cottages in South San Francisco
- South San Francisco Hotels
- Houseboat Rentals in South San Francisco
- Air Canada Toronto (YTZ) to San Francisco (SFO) flights
- Air Canada Penticton (YYF) to San Francisco (SFO) flights
- Air Canada Vancouver (YVR) to San Francisco (SFO) flights
- Air New Zealand Auckland (AKL) to San Francisco (SFO) flights
- Alaska Airlines Edmonton (YEG) to San Francisco (SFO) flights
- Alaska Airlines Orlando (MCO) to San Francisco (SFO) flights
- Alaska Airlines Portland (PDX) to San Francisco (SFO) flights
- Alaska Airlines Vancouver (YVR) to San Francisco (SFO) flights
- American Airlines Hartford (BDL) to San Francisco (SFO) flights
- American Airlines Dallas (DFW) to San Francisco (SFO) flights
- Cathay Pacific Hong Kong (HKG) to San Francisco (SFO) flights
- Delta Buffalo (BUF) to San Francisco (SFO) flights
- Delta Detroit (DTW) to San Francisco (SFO) flights
- Delta London (LHR) to San Francisco (SFO) flights
- Delta Los Angeles (LAX) to San Francisco (SFO) flights
- Delta Ontario (ONT) to San Francisco (SFO) flights
- Delta Toronto (YYZ) to San Francisco (SFO) flights
- Delta Washington (DCA) to San Francisco (SFO) flights
- Delta Vancouver (YVR) to San Francisco (SFO) flights
- Jetblue Airways Fort Lauderdale (FLL) to San Francisco (SFO) flights
- Jetblue Airways Boston (BOS) to San Francisco (SFO) flights
- Jetblue Airways San Juan (SJU) to San Francisco (SFO) flights
- Qantas Airways Melbourne (MEL) to San Francisco (SFO) flights
- Qatar Airways Lahore (LHE) to San Francisco (SFO) flights
- Qatar Airways Chennai (MAA) to San Francisco (SFO) flights
- United New York (LGA) to San Francisco (SFO) flights
- United Puerto Vallarta (PVR) to San Francisco (SFO) flights
- United Chicago (ORD) to San Francisco (SFO) flights
- United San Luis Obispo (SBP) to San Francisco (SFO) flights
- United Amsterdam (AMS) to San Francisco (SFO) flights
- United Tampa (TPA) to San Francisco (SFO) flights
- United Vancouver (YVR) to San Francisco (SFO) flights
- Virgin Atlantic London (LHR) to San Francisco (SFO) flights
- Westjet Kitchener (YKF) to San Francisco (SFO) flights
- Westjet Seattle (SEA) to San Francisco (SFO) flights
- Westjet Vancouver (YVR) to San Francisco (SFO) flights
- Flights from Bellingham (BLI) to San Francisco (SFO)
- Flights from Bronnoysund (BNN) to San Francisco (SFO)
- Flights from Boise (BOI) to San Francisco (SFO)
- Flights from Burlington (BTV) to San Francisco (SFO)
- Flights from Buffalo (BUF) to San Francisco (SFO)
- Flights from Christchurch (CHC) to San Francisco (SFO)
- Flights from Charlotte (CLT) to San Francisco (SFO)
- Flights from Dallas (DAL) to San Francisco (SFO)
- Flights from Dallas (DFW) to San Francisco (SFO)
- Flights from Newark Liberty Intl. Airport (EWR) to San Francisco (SFO)
- Flights from Houston (HOU) to San Francisco (SFO)
- Flights from Las Vegas (LAS) to San Francisco (SFO)
- Flights from Merida (MID) to San Francisco (SFO)
- Flights from Minot (MOT) to San Francisco (SFO)
- Flights from Minneapolis (MSP) to San Francisco (SFO)
- Flights from Ocho Rios (OCJ) to San Francisco (SFO)
- Flights from Chicago (ORD) to San Francisco (SFO)
- Flights from Portland (PDX) to San Francisco (SFO)
- Flights from Palm Springs (PSP) to San Francisco (SFO)
- Flights from Rochester (ROC) to San Francisco (SFO)
- Flights from Seattle (SEA) to San Francisco (SFO)
- Flights from Salt Lake City (SLC) to San Francisco (SFO)
- Flights from Orange County (SNA) to San Francisco (SFO)
- Flights from St. Louis (STL) to San Francisco (SFO)
- Flights from Can Tho (VCA) to San Francisco (SFO)
- Flights from Hamilton (YHM) to San Francisco (SFO)
- Flights from Halifax (YHZ) to San Francisco (SFO)
- Flights from Windsor (YQG) to San Francisco (SFO)
- Flights from Moncton (YQM) to San Francisco (SFO)
- Flights from Vancouver (YVR) to San Francisco (SFO)
- Flights from Calgary (YYC) to San Francisco (SFO)
- Flights from Victoria (YYJ) to San Francisco (SFO)
- Flights from Toronto (YYZ) to San Francisco (SFO)





