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Featured South San Francisco 4 Star hotels

Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

4 out of 5
2500 Mason St San Francisco CA
Fully refundableReserve now, pay when you stay
The price is CA $196 per night from Jul 6 to Jul 7
CA $196
CA $288 total
Jul 6 - Jul 7
includes taxes & fees
Book a stay at this business-friendly hotel in San Francisco. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast ...
9/10 Wonderful! (7,581 reviews)
"The best of the seven hotels we stayed in on our West Coast road trip. Amazing breakfast, super helpful team of staff, perfect nights sleep... great location away from the main city centre."

Reviewed on Jun 12, 2026

Opens in a new windowHotel Riu Plaza Fisherman's Wharf
Hyatt Regency San Francisco

Hyatt Regency San Francisco

4 out of 5
5 Embarcadero Center San Francisco CA
Fully refundableReserve now, pay when you stay
The price is CA $275 per night from Jun 19 to Jun 20
CA $275
CA $388 total
Jun 19 - Jun 20
includes taxes & fees
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and ...
9.2/10 Wonderful! (2,293 reviews)
"All good"

Reviewed on Jun 11, 2026

Opens in a new windowHyatt Regency San Francisco
Oakland Marriott City Center

Oakland Marriott City Center

4 out of 5
1001 Broadway Oakland CA
Fully refundableReserve now, pay when you stay
The price is CA $156 per night from Jul 5 to Jul 6
CA $156
CA $182 total
Jul 5 - Jul 6
includes taxes & fees
Book a stay at this golf hotel in Oakland. Enjoy breakfast (surcharge), room service, and a 24-hour fitness center. Our guests praise the helpful staff and the ...
9/10 Wonderful! (1,019 reviews)
"Iron restaurant was closed, each time i went. no sign telling operating hours."

Reviewed on Jun 9, 2026

Opens in a new windowOakland Marriott City Center
DoubleTree by Hilton Hotel Berkeley Marina

DoubleTree by Hilton Hotel Berkeley Marina

4 out of 5
200 Marina Blvd Berkeley CA
Fully refundableReserve now, pay when you stay
The price is CA $147 per night from Jul 5 to Jul 6
CA $147
CA $170 total
Jul 5 - Jul 6
includes taxes & fees
Book a stay at this business-friendly hotel in Berkeley. Enjoy free WiFi, a marina, and breakfast (surcharge). Our guests praise the breakfast and the restaurant ...
8.2/10 Very Good! (4,753 reviews)
"No complimentary hot tea or coffee in the lobby."

Reviewed on Jun 11, 2026

Opens in a new windowDoubleTree by Hilton Hotel Berkeley Marina
Hilton San Francisco Union Square

Hilton San Francisco Union Square

4 out of 5
333 O'Farrell St. San Francisco CA
Fully refundableReserve now, pay when you stay
The price is CA $205 per night from Jul 3 to Jul 4
CA $205
CA $241 total
Jul 3 - Jul 4
includes taxes & fees
Book a stay at this business-friendly hotel in San Francisco. Enjoy 2 bars/lounges, breakfast (surcharge), and a 24-hour health club. Our guests praise the helpful ...
8.6/10 Excellent! (1,364 reviews)
"Inside was fairly clean. The outside could use a power spray cleaning at least every week from the smell of urine. Luggage Staff was extremely helpful. Check-in Staff that helped me could be more friendly to encourage customers to come back. Overall stay was okay to good."

Reviewed on Jun 8, 2026

Opens in a new windowHilton San Francisco Union Square
Grand Hyatt at SFO

Grand Hyatt at SFO

4 out of 5
55 S McDonnell Rd San Francisco CA
Fully refundableReserve now, pay when you stay
The price is CA $331 per night from Jun 26 to Jun 27
CA $331
CA $369 total
Jun 26 - Jun 27
includes taxes & fees
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Our guests praise the restaurant ...
9.8/10 Exceptional! (1,632 reviews)
"Beautiful property at the airport! Would ABSOLUTELY stay here again!"

Reviewed on Jun 11, 2026

Opens in a new windowGrand Hyatt at SFO
Hyatt Regency San Francisco Airport

Hyatt Regency San Francisco Airport

4 out of 5
1333 Bayshore Hwy Burlingame CA
Fully refundableReserve now, pay when you stay
The price is CA $189 per night from Jul 12 to Jul 13
CA $189
CA $253 total
Jul 12 - Jul 13
includes taxes & fees
Book a stay at this family-friendly hotel in Burlingame. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the restaurant ...
9/10 Wonderful! (1,383 reviews)
"Wont stay here again. Parking $50 for a mid-peninsula hotel w plenty of space. Several other nice hotels in area that dont charge foe parking. Then my room was a 5 min walk from the elevator- poor layout. And lastly, nickel and diming - i had an amazon package sent there amd they charged me $4 for ..."

Reviewed on Jun 10, 2026

Opens in a new windowHyatt Regency San Francisco Airport
DoubleTree by Hilton San Francisco South Airport Blvd

DoubleTree by Hilton San Francisco South Airport Blvd

4 out of 5
275 S Airport Blvd South San Francisco CA
Fully refundableReserve now, pay when you stay
The price is CA $158 per night from Jul 11 to Jul 12
CA $158
CA $186 total
Jul 11 - Jul 12
includes taxes & fees
Book a stay at this business-friendly hotel in South San Francisco. Enjoy free WiFi, a free airport shuttle, and a fitness center. Our guests praise the restaurant ...
8.4/10 Very Good! (2,338 reviews)
"Limited parking and would I would have appreciated having a property map to see open spaces closer to our room entrance."

Reviewed on Jun 11, 2026

Opens in a new windowDoubleTree by Hilton San Francisco South Airport Blvd
Club Quarters Hotel in San Francisco

Club Quarters Hotel in San Francisco

4 out of 5
424 Clay St San Francisco CA
Fully refundableReserve now, pay when you stay
The price is CA $180 per night from Jul 2 to Jul 3
CA $180
CA $211 total
Jul 2 - Jul 3
includes taxes & fees
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and ...
9/10 Wonderful! (3,234 reviews)
"Club Quarters was good enough. It Definitely looks nicer online, but is clean and the bed was comfortable. Add $45 a day if you have a car to park in the Parking Structure across the street."

Reviewed on Jun 11, 2026

Opens in a new windowClub Quarters Hotel in San Francisco
San Francisco Marriott Marquis

San Francisco Marriott Marquis

4 out of 5
780 Mission Street San Francisco CA
Fully refundableReserve now, pay when you stay
The price is CA $233 per night from Jul 3 to Jul 4
CA $233
CA $338 total
Jul 3 - Jul 4
includes taxes & fees
Book a stay at this business-friendly hotel in San Francisco. Enjoy 2 restaurants, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the ...
8.8/10 Excellent! (1,227 reviews)
"Location was great. We loved the bar on the 39th floor. Beds were great."

Reviewed on Jun 11, 2026

Opens in a new windowSan Francisco Marriott Marquis
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4 Star Hotels South San Francisco

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in South San Francisco 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in South San Francisco will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in South San Francisco, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

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