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Featured South San Francisco 4 Star hotels

Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

4 out of 5
2500 Mason St San Francisco CA
Fully refundableReserve now, pay when you stay
The price is CA $193 per night from Apr 12 to Apr 13
CA $193
CA $283 total
Apr 12 - Apr 13
includes taxes & fees
Book a stay at this business-friendly hotel in San Francisco. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast ...
9/10 Wonderful! (7,335 reviews)
Room was small and very outdated definitely not worth the 400+ a night price

Reviewed on Mar 12, 2026

Opens in a new windowHotel Riu Plaza Fisherman's Wharf
DoubleTree by Hilton Hotel Berkeley Marina

DoubleTree by Hilton Hotel Berkeley Marina

4 out of 5
200 Marina Blvd Berkeley CA
Fully refundableReserve now, pay when you stay
The price is CA $153 per night from Mar 15 to Mar 16
CA $153
CA $176 total
Mar 15 - Mar 16
includes taxes & fees
Book a stay at this business-friendly hotel in Berkeley. Enjoy free WiFi, a marina, and breakfast (surcharge). Our guests praise the breakfast and the restaurant ...
8.2/10 Very Good! (4,363 reviews)
This was great

Reviewed on Mar 13, 2026

Opens in a new windowDoubleTree by Hilton Hotel Berkeley Marina
Grand Hyatt at SFO

Grand Hyatt at SFO

4 out of 5
55 S McDonnell Rd San Francisco CA
Fully refundableReserve now, pay when you stay
The price is CA $394 per night from Apr 5 to Apr 6
CA $394
CA $440 total
Apr 5 - Apr 6
includes taxes & fees
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Our guests praise the restaurant ...
9.8/10 Exceptional! (1,519 reviews)
Convenient

Reviewed on Mar 13, 2026

Opens in a new windowGrand Hyatt at SFO
DoubleTree by Hilton San Francisco Airport

DoubleTree by Hilton San Francisco Airport

4 out of 5
835 Airport Blvd Burlingame CA
Fully refundableReserve now, pay when you stay
The price is CA $135 per night from Apr 3 to Apr 4
CA $135
CA $154 total
Apr 3 - Apr 4
includes taxes & fees
Book a stay at this business-friendly hotel in Burlingame. Enjoy breakfast (surcharge), a free airport shuttle, and room service. Our guests praise the helpful ...
8.6/10 Excellent! (1,482 reviews)
friendly stuff

Reviewed on Mar 13, 2026

Opens in a new windowDoubleTree by Hilton San Francisco Airport
Hilton San Francisco Financial District

Hilton San Francisco Financial District

4 out of 5
750 Kearny St San Francisco CA
The price is CA $138 per night from Apr 5 to Apr 6
CA $138
CA $162 total
Apr 5 - Apr 6
includes taxes & fees
Book a stay at this business-friendly hotel in San Francisco. Enjoy breakfast (surcharge), a fitness center, and WiFi (surcharge). Our guests praise the helpful ...
8.8/10 Excellent! (2,492 reviews)
Clean room and friendly staff

Reviewed on Mar 13, 2026

Opens in a new windowHilton San Francisco Financial District
Club Quarters Hotel in San Francisco

Club Quarters Hotel in San Francisco

4 out of 5
424 Clay St San Francisco CA
The price is CA $491 per night from Mar 22 to Mar 23
CA $491
CA $578 total
Mar 22 - Mar 23
includes taxes & fees
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and ...
9/10 Wonderful! (3,007 reviews)
Great location. Near the waterfront and North Beach (you can walk to everything. Unfortunately, my room needed a reno. The carpet, shower head and office chair need to go. I also don't think it was cleaned very well.

Reviewed on Mar 12, 2026

Opens in a new windowClub Quarters Hotel in San Francisco
Hyatt Regency San Francisco

Hyatt Regency San Francisco

4 out of 5
5 Embarcadero Center San Francisco CA
Fully refundableReserve now, pay when you stay
The price is CA $271 per night from Mar 21 to Mar 22
CA $271
CA $381 total
Mar 21 - Mar 22
includes taxes & fees
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and ...
9.2/10 Wonderful! (2,116 reviews)
Everything in walking distance.. Valet was amazing.. Comfortable

Reviewed on Mar 13, 2026

Opens in a new windowHyatt Regency San Francisco
Oakland Marriott City Center

Oakland Marriott City Center

4 out of 5
1001 Broadway Oakland CA
Fully refundableReserve now, pay when you stay
The price is CA $153 per night from Mar 29 to Mar 30
CA $153
CA $178 total
Mar 29 - Mar 30
includes taxes & fees
Book a stay at this golf hotel in Oakland. Enjoy breakfast (surcharge), room service, and a 24-hour fitness center. Our guests praise the helpful staff and the ...
9/10 Wonderful! (1,013 reviews)
Comfortable and clean

Reviewed on Mar 11, 2026

Opens in a new windowOakland Marriott City Center
Grand Hyatt San Francisco

Grand Hyatt San Francisco

4 out of 5
345 Stockton St San Francisco CA
Fully refundableReserve now, pay when you stay
The price is CA $199 per night from Mar 28 to Mar 29
CA $199
CA $299 total
Mar 28 - Mar 29
includes taxes & fees
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
9/10 Wonderful! (1,000 reviews)
The location and hotel itself were great. Check in was a breeze and we appreciated the waters we were given. We had alot of fun. Unfortunately the next day when we got our car back from the valet someone had stolen both our sunglasses from the center console. We know SF is notorious for car break ...

Reviewed on Mar 11, 2026

Opens in a new windowGrand Hyatt San Francisco
Hotel Zoe Fisherman's Wharf

Hotel Zoe Fisherman's Wharf

4 out of 5
425 North Point San Francisco CA
The price is CA $142 per night from Apr 12 to Apr 13
CA $142
CA $225 total
Apr 12 - Apr 13
includes taxes & fees
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the restaurant and ...
9.2/10 Wonderful! (1,761 reviews)
Great hotel. Very clean. Loved the modern/rugged style decor.

Reviewed on Mar 12, 2026

Opens in a new windowHotel Zoe Fisherman's Wharf
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4 Star Hotels South San Francisco

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in South San Francisco 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in South San Francisco will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in South San Francisco, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent South San Francisco hotel reviews by fellow wanderers

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