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Featured South San Francisco 4 Star hotels

Hyatt Regency San Francisco

Hyatt Regency San Francisco

4 out of 5
5 Embarcadero Center San Francisco CA
Fully refundableReserve now, pay when you stay
The price is CA $203 per night from Dec 14 to Dec 15
CA $203
CA $303 total
Dec 14 - Dec 15
includes taxes & fees
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and ...
9.2/10 Wonderful! (1,970 reviews)
Room is excellent

Reviewed on Nov 20, 2025

Opens in a new windowHyatt Regency San Francisco
DoubleTree by Hilton Hotel Berkeley Marina

DoubleTree by Hilton Hotel Berkeley Marina

4 out of 5
200 Marina Blvd Berkeley CA
Fully refundableReserve now, pay when you stay
The price is CA $208 per night from Dec 7 to Dec 8
CA $208
CA $239 total
Dec 7 - Dec 8
includes taxes & fees
Book a stay at this business-friendly hotel in Berkeley. Enjoy free WiFi, a marina, and breakfast (surcharge). Our guests praise the breakfast and the restaurant ...
8.2/10 Very Good! (3,780 reviews)
The staffs are friendly and helpful. But the building and facilities are a bit old

Reviewed on Nov 21, 2025

Opens in a new windowDoubleTree by Hilton Hotel Berkeley Marina
Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

4 out of 5
2500 Mason St San Francisco CA
Fully refundableReserve now, pay when you stay
The price is CA $159 per night from Nov 24 to Nov 25
CA $159
CA $246 total
Nov 24 - Nov 25
includes taxes & fees
Book a stay at this business-friendly hotel in San Francisco. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast ...
8.8/10 Excellent! (7,106 reviews)
Everything as or better than expected!

Reviewed on Nov 20, 2025

Opens in a new windowHotel Riu Plaza Fisherman's Wharf
Hilton San Francisco Financial District

Hilton San Francisco Financial District

4 out of 5
750 Kearny St San Francisco CA
Fully refundableReserve now, pay when you stay
The price is CA $131 per night from Dec 22 to Dec 23
CA $131
CA $154 total
Dec 22 - Dec 23
includes taxes & fees
Book a stay at this business-friendly hotel in San Francisco. Enjoy breakfast (surcharge), a fitness center, and WiFi (surcharge). Our guests praise the helpful ...
8.6/10 Excellent! (2,020 reviews)
Best ever thank you

Reviewed on Nov 17, 2025

Opens in a new windowHilton San Francisco Financial District
Club Quarters Hotel in San Francisco

Club Quarters Hotel in San Francisco

4 out of 5
424 Clay St San Francisco CA
Fully refundableReserve now, pay when you stay
The price is CA $136 per night from Nov 23 to Nov 24
CA $136
CA $160 total
Nov 23 - Nov 24
includes taxes & fees
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and ...
8.8/10 Excellent! (2,734 reviews)
Excellent hotel would recommend to all my friends

Reviewed on Nov 16, 2025

Opens in a new windowClub Quarters Hotel in San Francisco
InterContinental Mark Hopkins by IHG

InterContinental Mark Hopkins by IHG

4 out of 5
999 California Street San Francisco CA
Fully refundable
The price is CA $197 per night from Nov 25 to Nov 26
CA $197
CA $282 total
Nov 25 - Nov 26
includes taxes & fees
Book a stay at this luxury hotel in San Francisco. Enjoy breakfast (surcharge), room service, and a fitness center. Our guests praise the helpful staff and the ...
9/10 Wonderful! (1,184 reviews)
The room had lovely views, a nice long corridor as you enter the room. The bed was well appointed and comfortable. The staff was pleasant and accommodating.

Reviewed on Nov 20, 2025

Opens in a new windowInterContinental Mark Hopkins by IHG
Kimpton Alton Fisherman's Wharf by IHG

Kimpton Alton Fisherman's Wharf by IHG

4.5 out of 5
2700 JONES STREET San Francisco CA
Fully refundable
The price is CA $157 per night from Nov 30 to Dec 1
CA $157
CA $242 total
Nov 30 - Dec 1
includes taxes & fees
Book a stay at this luxury hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful staff ...
9/10 Wonderful! (1,529 reviews)
Great location and great staff. Will do again!

Reviewed on Nov 21, 2025

Opens in a new windowKimpton Alton Fisherman's Wharf by IHG
Grand Hyatt at SFO

Grand Hyatt at SFO

4 out of 5
55 S McDonnell Rd San Francisco CA
Fully refundableReserve now, pay when you stay
The price is CA $407 per night from Dec 22 to Dec 23
CA $407
CA $455 total
Dec 22 - Dec 23
includes taxes & fees
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Our guests praise the restaurant ...
9.6/10 Exceptional! (1,442 reviews)
Safety , rooms were clean, beds comfortable drinks good as well as the food. A little pricey

Reviewed on Nov 18, 2025

Opens in a new windowGrand Hyatt at SFO
Oakland Marriott City Center

Oakland Marriott City Center

4 out of 5
1001 Broadway Oakland CA
Fully refundableReserve now, pay when you stay
The price is CA $156 per night from Dec 21 to Dec 22
CA $156
CA $182 total
Dec 21 - Dec 22
includes taxes & fees
Book a stay at this golf hotel in Oakland. Enjoy breakfast (surcharge), room service, and a 24-hour fitness center. Our guests praise the helpful staff and the ...
8.8/10 Excellent! (1,006 reviews)
Close to venue. Room was decent

Reviewed on Nov 16, 2025

Opens in a new windowOakland Marriott City Center
Hilton San Francisco Airport Bayfront

Hilton San Francisco Airport Bayfront

4 out of 5
600 Airport Boulevard Burlingame CA
Fully refundableReserve now, pay when you stay
The price is CA $132 per night from Dec 23 to Dec 24
CA $132
CA $150 total
Dec 23 - Dec 24
includes taxes & fees
Book a stay at this business-friendly hotel in Burlingame. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the breakfast ...
8.4/10 Very Good! (2,711 reviews)
Room was great, staff was wonderful

Reviewed on Nov 20, 2025

Opens in a new windowHilton San Francisco Airport Bayfront
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4 Star Hotels South San Francisco

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in South San Francisco 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in South San Francisco will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in South San Francisco, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent South San Francisco hotel reviews by fellow wanderers