Find and compare 4 Star hotels in South San Francisco

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Featured South San Francisco 4 Star hotels

Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

4 out of 5
2500 Mason St, San Francisco, CA
Fully refundableReserve now, pay when you stay
The price is CA $197 per night from Nov 5 to Nov 6
CA $197
CA $290 total
Nov 5 - Nov 6
includes taxes & fees
Book a stay at this eco-certified hotel in San Francisco. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...
8.8/10 Excellent! (6,898 reviews)
"Nice upgrade, clean room, friendly staff, wonderful breakfast, fantastic location."

Reviewed on Oct 1, 2025

Opens in a new windowHotel Riu Plaza Fisherman's Wharf
Hyatt Regency San Francisco

Hyatt Regency San Francisco

4 out of 5
5 Embarcadero Center, San Francisco, CA
Fully refundableReserve now, pay when you stay
The price is CA $277 per night from Oct 11 to Oct 12
CA $277
CA $392 total
Oct 11 - Oct 12
includes taxes & fees
Stay at this 4-star eco-certified hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the ...
9.2/10 Wonderful! (1,914 reviews)
"Really enjoyed our stay at this beautiful hotel."

Reviewed on Oct 4, 2025

Opens in a new windowHyatt Regency San Francisco
Hilton San Francisco Financial District

Hilton San Francisco Financial District

4 out of 5
750 Kearny St, San Francisco, CA
Fully refundableReserve now, pay when you stay
The price is CA $151 per night from Nov 2 to Nov 3
CA $151
CA $178 total
Nov 2 - Nov 3
includes taxes & fees
Book a stay at this business-friendly hotel in San Francisco. Enjoy breakfast (surcharge), a fitness center, and WiFi (surcharge). Our guests praise the helpful ...
8.6/10 Excellent! (1,829 reviews)
"Conveniently location close to China town and financial centre."

Reviewed on Oct 1, 2025

Opens in a new windowHilton San Francisco Financial District
Club Quarters Hotel in San Francisco

Club Quarters Hotel in San Francisco

4 out of 5
424 Clay St, San Francisco, CA
Fully refundableReserve now, pay when you stay
The price is CA $183 per night from Oct 17 to Oct 18
CA $183
CA $216 total
Oct 17 - Oct 18
includes taxes & fees
Stay at this 4-star business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and ...
8.8/10 Excellent! (2,634 reviews)
"Great location"

Reviewed on Oct 4, 2025

Opens in a new windowClub Quarters Hotel in San Francisco
Hyatt Centric Fisherman's Wharf San Francisco

Hyatt Centric Fisherman's Wharf San Francisco

4 out of 5
555 N Point St, San Francisco, CA
Fully refundableReserve now, pay when you stay
The price is CA $188 per night from Nov 2 to Nov 3
CA $188
CA $279 total
Nov 2 - Nov 3
includes taxes & fees
Stay at this 4-star business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the breakfast ...
8.6/10 Excellent! (1,416 reviews)
"Staff courteous"

Reviewed on Oct 2, 2025

Opens in a new windowHyatt Centric Fisherman's Wharf San Francisco
DoubleTree by Hilton Hotel Berkeley Marina

DoubleTree by Hilton Hotel Berkeley Marina

4 out of 5
200 Marina Blvd, Berkeley, CA
Fully refundableReserve now, pay when you stay
The price is CA $160 per night from Oct 30 to Oct 31
CA $160
CA $185 total
Oct 30 - Oct 31
includes taxes & fees
Stay at this 4-star eco-certified hotel in Berkeley. Enjoy free WiFi, a marina, and breakfast (surcharge). Our guests praise the breakfast and the restaurant ...
8.2/10 Very Good! (3,466 reviews)
"It was a perfect hotel and a perfect spot. Everyone was great thank you"

Reviewed on Oct 4, 2025

Opens in a new windowDoubleTree by Hilton Hotel Berkeley Marina
Grand Hyatt San Francisco

Grand Hyatt San Francisco

4 out of 5
345 Stockton St, San Francisco, CA
Fully refundableReserve now, pay when you stay
The price is CA $212 per night from Oct 31 to Nov 1
CA $212
CA $315 total
Oct 31 - Nov 1
includes taxes & fees
Book a stay at this eco-certified hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
8.8/10 Excellent! (1,001 reviews)
"Great staff, great breakfast buffet, clean rooms. The only thing that is odd is how many additional fees you have to pay by the time you leave. I knew going into it I’d be paying a rate per day in additional fees, but when I checked out I had to provide my card again for it to be charged once more. ..."

Reviewed on Sep 28, 2025

Opens in a new windowGrand Hyatt San Francisco
The Westin San Francisco Airport

The Westin San Francisco Airport

4 out of 5
1 Old Bayshore Hwy, Millbrae, CA
Fully refundableReserve now, pay when you stay
The price is CA $167 per night from Oct 25 to Oct 26
CA $167
CA $233 total
Oct 25 - Oct 26
includes taxes & fees
Book a stay at this business-friendly hotel in Millbrae. Enjoy breakfast (surcharge), a free airport shuttle, and a 24-hour fitness center. Our guests praise ...
8.8/10 Excellent! (2,040 reviews)
"smooth professional check-in, clean room, great view, nice amenities"

Reviewed on Oct 3, 2025

Opens in a new windowThe Westin San Francisco Airport
Grand Hyatt at SFO

Grand Hyatt at SFO

4 out of 5
55 S McDonnell Rd, San Francisco, CA
Fully refundableReserve now, pay when you stay
The price is CA $417 per night from Oct 11 to Oct 12
CA $417
CA $466 total
Oct 11 - Oct 12
includes taxes & fees
Stay at this 4-star business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Our guests praise the restaurant ...
9.6/10 Exceptional! (1,421 reviews)
"Amazing place to stay if you have a flight out of SFO, just jump on your flight straight from your room."

Reviewed on Oct 6, 2025

Opens in a new windowGrand Hyatt at SFO
Parc 55 San Francisco - A Hilton Hotel

Parc 55 San Francisco - A Hilton Hotel

4 out of 5
55 Cyril Magnin St, San Francisco, CA
Fully refundableReserve now, pay when you stay
The price is CA $182 per night from Oct 31 to Nov 1
CA $182
CA $275 total
Oct 31 - Nov 1
includes taxes & fees
Stay at this 4-star business-friendly hotel in San Francisco. Enjoy 2 restaurants, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the ...
8.6/10 Excellent! (1,431 reviews)
"Friendly and welcoming staff"

Reviewed on Oct 1, 2025

Opens in a new windowParc 55 San Francisco - A Hilton Hotel
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4 Star Hotels South San Francisco

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in South San Francisco 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in South San Francisco will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in South San Francisco, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent South San Francisco hotel reviews by fellow wanderers