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Featured South San Francisco 4 Star hotels

Hyatt Regency San Francisco

Hyatt Regency San Francisco

4 out of 5
5 Embarcadero Center San Francisco CA
Fully refundableReserve now, pay when you stay
The price is CA $236 per night from Feb 13 to Feb 14
CA $236
CA $342 total
Feb 13 - Feb 14
includes taxes & fees
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and ...
9.2/10 Wonderful! (2,039 reviews)
Parking was easy, staff was AMAZING.

Reviewed on Jan 13, 2026

Opens in a new windowHyatt Regency San Francisco
DoubleTree by Hilton Hotel Berkeley Marina

DoubleTree by Hilton Hotel Berkeley Marina

4 out of 5
200 Marina Blvd Berkeley CA
Fully refundableReserve now, pay when you stay
The price is CA $156 per night from Jan 25 to Jan 26
CA $156
CA $180 total
Jan 25 - Jan 26
includes taxes & fees
Book a stay at this business-friendly hotel in Berkeley. Enjoy free WiFi, a marina, and breakfast (surcharge). Our guests praise the breakfast and the restaurant ...
8.2/10 Very Good! (4,133 reviews)
Good service, excellent staff at the front desk. Very nice room accommodation.

Reviewed on Jan 13, 2026

Opens in a new windowDoubleTree by Hilton Hotel Berkeley Marina
Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

4 out of 5
2500 Mason St San Francisco CA
Fully refundableReserve now, pay when you stay
The price is CA $149 per night from Jan 25 to Jan 26
CA $149
CA $233 total
Jan 25 - Jan 26
includes taxes & fees
Book a stay at this business-friendly hotel in San Francisco. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast ...
8.8/10 Excellent! (7,252 reviews)
Excellent place to stay excellent breakfast in the morning, the only thing I didn’t like is having to pay for parking $60 a night and across the street was a parking ramp for $40 a night.

Reviewed on Jan 13, 2026

Opens in a new windowHotel Riu Plaza Fisherman's Wharf
Hilton San Francisco Financial District

Hilton San Francisco Financial District

4 out of 5
750 Kearny St San Francisco CA
Fully refundableReserve now, pay when you stay
The price is CA $151 per night from Feb 16 to Feb 17
CA $151
CA $177 total
Feb 16 - Feb 17
includes taxes & fees
Book a stay at this business-friendly hotel in San Francisco. Enjoy breakfast (surcharge), a fitness center, and WiFi (surcharge). Our guests praise the helpful ...
8.6/10 Excellent! (2,280 reviews)
Very clean room. Service is very friendly and efficient.

Reviewed on Jan 14, 2026

Opens in a new windowHilton San Francisco Financial District
Club Quarters Hotel in San Francisco

Club Quarters Hotel in San Francisco

4 out of 5
424 Clay St San Francisco CA
Fully refundableReserve now, pay when you stay
The price is CA $207 per night from Jan 18 to Jan 19
CA $207
CA $244 total
Jan 18 - Jan 19
includes taxes & fees
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and ...
8.8/10 Excellent! (2,904 reviews)
For the $ and the what you get and location. Its great.

Reviewed on Jan 15, 2026

Opens in a new windowClub Quarters Hotel in San Francisco
InterContinental Mark Hopkins by IHG

InterContinental Mark Hopkins by IHG

4 out of 5
999 California Street San Francisco CA
Fully refundable
The price is CA $221 per night from Feb 16 to Feb 17
CA $221
CA $318 total
Feb 16 - Feb 17
includes taxes & fees
Book a stay at this luxury hotel in San Francisco. Enjoy breakfast (surcharge), room service, and a fitness center. Our guests praise the helpful staff and the ...
9/10 Wonderful! (1,270 reviews)
Super friendly staff and room was perfect

Reviewed on Jan 7, 2026

Opens in a new windowInterContinental Mark Hopkins by IHG
Kimpton Alton Fisherman's Wharf by IHG

Kimpton Alton Fisherman's Wharf by IHG

4.5 out of 5
2700 JONES STREET San Francisco CA
Fully refundable
The price is CA $189 per night from Feb 16 to Feb 17
CA $189
CA $281 total
Feb 16 - Feb 17
includes taxes & fees
Book a stay at this luxury hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful staff ...
9/10 Wonderful! (1,522 reviews)
The hotel was spotless and really friendly staff, I arrived at 10am after a long flight and they allowed me to check in early as they had a room available, very thankful for that. I would highly recommend and would stay here again in the future.

Reviewed on Jan 11, 2026

Opens in a new windowKimpton Alton Fisherman's Wharf by IHG
Grand Hyatt at SFO

Grand Hyatt at SFO

4 out of 5
55 S McDonnell Rd San Francisco CA
Fully refundableReserve now, pay when you stay
The price is CA $429 per night from Jan 18 to Jan 19
CA $429
CA $479 total
Jan 18 - Jan 19
includes taxes & fees
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Our guests praise the restaurant ...
9.6/10 Exceptional! (1,471 reviews)
Great hotel, room and people. Highly recommended

Reviewed on Jan 11, 2026

Opens in a new windowGrand Hyatt at SFO
Oakland Marriott City Center

Oakland Marriott City Center

4 out of 5
1001 Broadway Oakland CA
Fully refundableReserve now, pay when you stay
The price is CA $176 per night from Jan 30 to Jan 31
CA $176
CA $205 total
Jan 30 - Jan 31
includes taxes & fees
Book a stay at this golf hotel in Oakland. Enjoy breakfast (surcharge), room service, and a 24-hour fitness center. Our guests praise the helpful staff and the ...
8.8/10 Excellent! (1,016 reviews)
It was good

Reviewed on Jan 10, 2026

Opens in a new windowOakland Marriott City Center
Hilton San Francisco Airport Bayfront

Hilton San Francisco Airport Bayfront

4 out of 5
600 Airport Boulevard Burlingame CA
Fully refundableReserve now, pay when you stay
The price is CA $136 per night from Jan 30 to Jan 31
CA $136
CA $154 total
Jan 30 - Jan 31
includes taxes & fees
Book a stay at this business-friendly hotel in Burlingame. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the breakfast ...
8.4/10 Very Good! (2,893 reviews)
Location was good, the hotel was nice and clean. The reason for a 4 star instead of 5 is that parking was $40/day and shuttle only goes to the airport and not downtown Burlingame.

Reviewed on Jan 13, 2026

Opens in a new windowHilton San Francisco Airport Bayfront
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4 Star Hotels South San Francisco

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in South San Francisco 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in South San Francisco will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in South San Francisco, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent South San Francisco hotel reviews by fellow wanderers