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Hotels near Otay Mesa
The Dana on Mission Bay
1710 W Mission Bay Dr San Diego CA
Fully refundableReserve now, pay when you stay
The price is CA $222 per night from Sep 28 to Sep 29
CA $222
CA $295 total
Sep 28 - Sep 29
includes taxes & fees
Stay at this hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in our reviews. Popular attractions ...
"Room was clean, cleaning lady was very nice through out are stay. The staff was not that helpful I felt I was the employee and the staff was royalty I was serving them. Monday when we got there went to the pool very nice, lady asked would you like 🍸's yes please and she took care of us, but the ..."
Reviewed on Sep 4, 2026
Hard Rock Hotel San Diego
207 5th Ave San Diego CA
Fully refundableReserve now, pay when you stay
The price is CA $236 per night from Sep 28 to Sep 29
CA $236
CA $340 total
Sep 28 - Sep 29
includes taxes & fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ...
"We had a suite which was clean and neat. Issues were promptly repaired. The room had a strange configuration with frosted glass doors for the shower and toilet areas that could be seen from sitting area...thus lacking privacy. We had one drink at the bar but did not otherwise eat or drink at the ..."
Reviewed on Sep 5, 2026
Paradise Point Resort & Spa
1404 Vacation Rd San Diego CA
Fully refundableReserve now, pay when you stay
The price is CA $288 per night from Oct 4 to Oct 5
CA $288
CA $404 total
Oct 4 - Oct 5
includes taxes & fees
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
"Beautiful resort and really lovely staff! We had a fantastic visit. (Only downside: The air conditioning unit was noisy and way under par considering how great the room was in every other way.)"
Reviewed on Sep 5, 2026
Best Western Seven Seas
411 Hotel Circle South San Diego CA
Fully refundableReserve now, pay when you stay
The price is CA $117 per night from Sep 22 to Sep 23
CA $117
CA $134 total
Sep 22 - Sep 23
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, free parking, and 2 hot tubs. Our guests praise the pool and the restaurant in our ...
"They were renovating and work started at 7am, they moved me to an area which was no longer under construction however not only was that not the case but every time Someone ran water there was a very load noise until they turned off the water so it was impossible to get any rest."
Reviewed on Sep 4, 2026
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2296 Niels Bohr Ct San Diego CA
Fully refundable
The price is CA $190 per night from Oct 5 to Oct 6
CA $190
CA $216 total
Oct 5 - Oct 6
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Manchester Grand Hyatt San Diego
1 Market Pl San Diego CA
Fully refundableReserve now, pay when you stay
The price is CA $275 per night from Sep 7 to Sep 8
CA $275
CA $395 total
Sep 7 - Sep 8
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy 6 restaurants, 3 bars/lounges, and breakfast (surcharge). Our guests praise the pool and the ...
Wyndham San Diego Bayside
1355 N Harbor Drive San Diego CA
Fully refundableReserve now, pay when you stay
The price is CA $210 per night from Sep 20 to Sep 21
CA $210
CA $291 total
Sep 20 - Sep 21
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
The Sofia Hotel
150 W Broadway San Diego CA
Fully refundableReserve now, pay when you stay
The price is CA $190 per night from Sep 29 to Sep 30
CA $190
CA $259 total
Sep 29 - Sep 30
includes taxes & fees
Book a stay at this historic hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the clean ...
Handlery Hotel
950 Hotel Cir N San Diego CA
Fully refundableReserve now, pay when you stay
The price is CA $153 per night from Sep 7 to Sep 8
CA $153
CA $176 total
Sep 7 - Sep 8
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the helpful staff ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
About Otay Mesa Hotels
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Recent Otay Mesa hotel reviews by fellow wanderers
Paradise Point Resort & Spa
5 out of 5
Posted 3 hours ago
Travelocity Verified Review
"Beautiful resort and really lovely staff! We had a fantastic visit. (Only downside: The air conditioning unit was noisy and way under par considering how great the room was in every other way.)"
A verified traveller stayed at Paradise Point Resort & Spa
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