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Hotels near Otay Mesa
Hard Rock Hotel San Diego
207 5th Ave San Diego CA
Fully refundableReserve now, pay when you stay
The price is CA $255 per night from Apr 7 to Apr 8
CA $255
CA $363 total
Apr 7 - Apr 8
includes taxes & fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ...
Clean room, helpful enthusiastic staff, and a nice hotel to stay at overall. The location is prime if you’re a baseball fan or going to an event at the convention center because the hotel is just across the street.
Reviewed on Apr 1, 2026
Manchester Grand Hyatt San Diego
1 Market Pl San Diego CA
The price is CA $277 per night from Apr 5 to Apr 6
CA $277
CA $397 total
Apr 5 - Apr 6
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the helpful staff ...
Great room and friendly staff
Reviewed on Apr 1, 2026
The DEXTRO Little Italy, BW Premier Collection
1617 1st Avenue San Diego CA
The price is CA $188 per night from Apr 23 to Apr 24
CA $188
CA $218 total
Apr 23 - Apr 24
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
Nice hotel
Reviewed on Apr 1, 2026
Paradise Point Resort & Spa
1404 Vacation Rd San Diego CA
Fully refundableReserve now, pay when you stay
The price is CA $316 per night from Apr 26 to Apr 27
CA $316
CA $437 total
Apr 26 - Apr 27
includes taxes & fees
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
Beautiful location, but our stay was disappointing due to several issues. We found a large bug in the room, the bathroom door got stuck and locked my son inside (maintenance said it had happened before), and the AC unit smelled strongly like urine when turned on. The shower also had visible buildup. ...
Reviewed on Apr 1, 2026
Handlery Hotel
950 Hotel Cir N San Diego CA
Fully refundableReserve now, pay when you stay
The price is CA $162 per night from Apr 21 to Apr 22
CA $162
CA $186 total
Apr 21 - Apr 22
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the helpful staff ...
Love the pool
Reviewed on Mar 31, 2026
Wyndham San Diego Bayside
1355 N Harbor Drive San Diego CA
Fully refundableReserve now, pay when you stay
The price is CA $212 per night from Apr 4 to Apr 5
CA $212
CA $294 total
Apr 4 - Apr 5
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
We went as a family of 4. Stayed 3 nights to check out the zoo and USS Midway. The elevator with the glass dome was a huge hit for the kids. We hit the pool every day. The onsite restaurants and gift shop had all the important things! Perfect for a home away from home for a few days.
Reviewed on Apr 1, 2026
Sheraton San Diego Resort
1380 Harbor Island Dr San Diego CA
Fully refundableReserve now, pay when you stay
The price is CA $174 per night from Apr 5 to Apr 6
CA $174
CA $261 total
Apr 5 - Apr 6
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
Overall, our family of 4’s stay was pleasant. The only thing was there was what I believe to be sewage gas backup coming out of the shower drain (room 440). Had the same experience at the Sheraton Toronto Airport, something about these older Sheraton hotels…
Reviewed on Mar 31, 2026
Days Inn by Wyndham San Diego Hotel Circle
543 Hotel Circle S San Diego CA
Fully refundableReserve now, pay when you stay
The price is CA $149 per night from Apr 26 to Apr 27
CA $149
CA $171 total
Apr 26 - Apr 27
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, a fitness center, and parking (surcharge). Our guests praise the helpful staff and ...
staff cleans daily if needed. nice front desk staff
Reviewed on Mar 31, 2026
Best Western Seven Seas
411 Hotel Circle South San Diego CA
Fully refundableReserve now, pay when you stay
The price is CA $114 per night from Apr 5 to Apr 6
CA $114
CA $131 total
Apr 5 - Apr 6
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, free parking, and 2 hot tubs. Our guests praise the pool and the restaurant in our ...
Clean, comfortable
Reviewed on Apr 1, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
About Otay Mesa Hotels
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Recent Otay Mesa hotel reviews by fellow wanderers
Hard Rock Hotel San Diego
5 out of 5
Posted 4 hours ago
Travelocity Verified Review
"Clean room, helpful enthusiastic staff, and a nice hotel to stay at overall. The location is prime if you’re a baseball fan or going to an event at the convention center because the hotel is just across the street. "
A verified traveller stayed at Hard Rock Hotel San Diego
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