Find a cheap Hotel in Otay Mesa

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Area
Area
Popular locations
Popular locations
Meal plans available
Meal plans available
Property amenities
Property amenities
Accessibility
Accessibility
Traveller experience
Traveller experience

Hotels near Otay Mesa

Bay Club Hotel & Marina

Bay Club Hotel & Marina

3.5 out of 5
2131 Shelter Island Dr San Diego CA
The price is CA $281 per night from Jul 7 to Jul 8
CA $281
CA $323 total
Jul 7 - Jul 8
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, a marina, and a health club. Our guests praise the breakfast and the restaurant in ...
"Great location, updated rooms. It was a little loud in the rooms i.e. we could hear guests walking/running upstairs and at the pool but that's expected. Staff in the bar and grill were busy so initially there interactions were not as expected but as we sat for sometime we got a friendly waitstaff ..."

Reviewed on Jul 1, 2026

Opens in a new windowBay Club Hotel & Marina
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
Fully refundableReserve now, pay when you stay
The price is CA $244 per night from Jul 5 to Jul 6
CA $244
CA $351 total
Jul 5 - Jul 6
includes taxes & fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ...
"Room was clean but dated"

Reviewed on Jun 30, 2026

Opens in a new windowHard Rock Hotel San Diego
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl San Diego CA
Fully refundableReserve now, pay when you stay
The price is CA $410 per night from Jul 2 to Jul 3
CA $410
CA $553 total
Jul 2 - Jul 3
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the helpful staff ...
"everything I could ask for in a hotel"

Reviewed on Jul 1, 2026

Opens in a new windowManchester Grand Hyatt San Diego
Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd San Diego CA
Fully refundableReserve now, pay when you stay
The price is CA $419 per night from Jul 6 to Jul 7
CA $419
CA $557 total
Jul 6 - Jul 7
includes taxes & fees
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
"Pool was great, my son loved it. I just found it difficult to sleep there with how muggy it feels in the rooms without the AC turned on. I can't sleep with it on becuase of the noise level, but with it off it was incredibly humid. Other than that, a very enjoyable place."

Reviewed on Jul 1, 2026

Opens in a new windowParadise Point Resort & Spa
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3 out of 5
1617 1st Avenue San Diego CA
Fully refundableReserve now, pay when you stay
The price is CA $220 per night from Jul 2 to Jul 3
CA $220
CA $256 total
Jul 2 - Jul 3
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
"center location , easy access and short drive distance to the zoo, museums and harbor"

Reviewed on Jun 30, 2026

Opens in a new windowThe DEXTRO Little Italy, BW Premier Collection
Bahia Resort Hotel

Bahia Resort Hotel

3.5 out of 5
998 W Mission Bay Dr San Diego CA
Fully refundableReserve now, pay when you stay
The price is CA $374 per night from Jul 7 to Jul 8
CA $374
CA $508 total
Jul 7 - Jul 8
includes taxes & fees
Book a stay at this beach resort in San Diego. Enjoy a beach locale, breakfast (surcharge), and 24-hour room service. Our guests praise the pool and the restaurant ...
"I love that it backs up to Mission Bay."

Reviewed on Jun 29, 2026

Opens in a new windowBahia Resort Hotel
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
Fully refundableReserve now, pay when you stay
The price is CA $216 per night from Jul 8 to Jul 9
CA $216
CA $300 total
Jul 8 - Jul 9
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
"Lost the power 4 times in my room I was not able to take shower and do My hair until hours later"

Reviewed on Jul 1, 2026

Opens in a new windowWyndham San Diego Bayside
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

2.5 out of 5
2296 Niels Bohr Ct San Diego CA
Fully refundable
The price is CA $247 per night from Aug 1 to Aug 2
CA $247
CA $281 total
Aug 1 - Aug 2
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
"Everything was clean and nice."

Reviewed on Jul 1, 2026

Opens in a new windowHoliday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

2.5 out of 5
2485 Hotel Circle Place San Diego CA
Fully refundableReserve now, pay when you stay
The price is CA $203 per night from Jul 2 to Jul 3
CA $203
CA $234 total
Jul 2 - Jul 3
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
"I will never make a reservation to this hotel. The room was unsatisfied for the sixth guest the mattress from the sofa bed. It was really bad and I will not recommend this hotel. Never close to Seaworld."

Reviewed on Jul 1, 2026

Opens in a new windowBest Western Inn & Suites San Diego – Zoo/SeaWorld Area
Don't see what you're looking for?
See all available properties in Otay Mesa
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Otay Mesa Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on Otay Mesa area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Otay Mesa to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Otay Mesa are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent Otay Mesa hotel reviews by fellow wanderers

Explore More Ways to Travel with Travelocity