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Hotels near Otay Mesa
Hampton Inn & Suites by Hilton San Diego SeaWorld
3888 Greenwood St San Diego CA
Fully refundableReserve now, pay when you stay
The price is CA $183 per night from Feb 22 to Feb 23
CA $183
CA $211 total
Feb 22 - Feb 23
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a fitness center. Popular attractions Mission Bay and Port of ...
I was very happy with my stay! From the moment I arrived, the front desk staff was welcoming and professional. The hotel was very clean, and the breakfast was excellent with great options. Everything exceeded my expectations. I would definitely stay here again!
Reviewed on Feb 11, 2026
Manchester Grand Hyatt San Diego
1 Market Pl San Diego CA
The price is CA $324 per night from Feb 26 to Feb 27
CA $324
CA $450 total
Feb 26 - Feb 27
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the helpful staff ...
My room was clean the hotel breakfast was excellent the staff and hotel are great! I love where this hotel is located always a good time until next year!
Reviewed on Feb 1, 2026
Hard Rock Hotel San Diego
207 5th Ave San Diego CA
Fully refundableReserve now, pay when you stay
The price is CA $254 per night from Feb 16 to Feb 17
CA $254
CA $359 total
Feb 16 - Feb 17
includes taxes & fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ...
Room was very clean and luxurious
Reviewed on Feb 5, 2026
The DEXTRO Little Italy, BW Premier Collection
1617 1st Avenue San Diego CA
Fully refundableReserve now, pay when you stay
The price is CA $157 per night from Feb 22 to Feb 23
CA $157
CA $183 total
Feb 22 - Feb 23
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
Staff were incredibly friendly and supportive
Reviewed on Feb 8, 2026
The Dana on Mission Bay
1710 W Mission Bay Dr San Diego CA
Fully refundableReserve now, pay when you stay
The price is CA $230 per night from Feb 23 to Feb 24
CA $230
CA $296 total
Feb 23 - Feb 24
includes taxes & fees
Stay at this hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in our reviews. Popular attractions ...
Clean rooms, but small. Good pools and amenities. Had to pay additional parking and resort fee.
Reviewed on Feb 7, 2026
Paradise Point Resort & Spa
1404 Vacation Rd San Diego CA
Fully refundableReserve now, pay when you stay
The price is CA $212 per night from Mar 1 to Mar 2
CA $212
CA $316 total
Mar 1 - Mar 2
includes taxes & fees
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
Spacious, nice rooms, beautiful resort, lots of activities. Only downside is $50 per night for parking by the room, though there is public parking on the property that we were not aware of.
Reviewed on Feb 8, 2026
The Sofia Hotel
150 W Broadway San Diego CA
Fully refundableReserve now, pay when you stay
Book a stay at this historic hotel in San Diego. Enjoy free WiFi, room service, and a 24-hour fitness center. Our guests praise the helpful staff and the clean ...
Location is close to Gaslamp district howvever seapoint village was cleaner and had nice restaurants and shops. The conference centre is a nice 15 to 20 minute walk from the hotel. The hotel manager Amy turned our stay around by listening issue with the AC and the fluff coming from it.We moved to ...
Reviewed on Feb 12, 2026
Wyndham San Diego Bayside
1355 N Harbor Drive San Diego CA
Fully refundableReserve now, pay when you stay
The price is CA $207 per night from Feb 16 to Feb 17
CA $207
CA $288 total
Feb 16 - Feb 17
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
The bed was horrible
Reviewed on Feb 7, 2026
Days Inn by Wyndham San Diego Hotel Circle
543 Hotel Circle S San Diego CA
Fully refundableReserve now, pay when you stay
The price is CA $108 per night from Feb 24 to Feb 25
CA $108
CA $125 total
Feb 24 - Feb 25
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, a fitness center, and parking (surcharge). Our guests praise the helpful staff and ...
Easy checkin
Reviewed on Feb 7, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
About Otay Mesa Hotels
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Get Started - Lets Roam Otay Mesa!
Recent Otay Mesa hotel reviews by fellow wanderers
The Sofia Hotel
5 out of 5
Posted 2 days ago
Travelocity Verified Review
"Fantastic location. It is just 10 mins walk to 5th avenue, 15 mins walk to the Portside pier, and the same distance to Little Italy.
"
A verified traveller stayed at The Sofia Hotel
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