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Hotels near Otay Mesa

Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
Fully refundableReserve now, pay when you stay
The price is CA $255 per night from Apr 2 to Apr 3
CA $255
CA $363 total
Apr 2 - Apr 3
includes taxes & fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ...
Didn’t have hand wash in bathroom

Reviewed on Mar 31, 2026

Opens in a new windowHard Rock Hotel San Diego
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl San Diego CA
The price is CA $403 per night from Apr 22 to Apr 23
CA $403
CA $543 total
Apr 22 - Apr 23
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the helpful staff ...
It’s a decent hotel more or less. Great location though.

Reviewed on Mar 30, 2026

Opens in a new windowManchester Grand Hyatt San Diego
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3 out of 5
1617 1st Avenue San Diego CA
The price is CA $188 per night from Apr 23 to Apr 24
CA $188
CA $218 total
Apr 23 - Apr 24
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
Parking is almost $40 per night. No WiFi(system down). Room dirty. Still waiting to get my deposit back after almost a week. Room is tiny.

Reviewed on Mar 31, 2026

Opens in a new windowThe DEXTRO Little Italy, BW Premier Collection
Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd San Diego CA
The price is CA $337 per night from Apr 26 to Apr 27
CA $337
CA $462 total
Apr 26 - Apr 27
includes taxes & fees
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
Very unique hotel property with lush grounds, lots of free family activities on site (e.g. mini golf, cornhole, pickleball), & 5 pools. Limited dining on site but Barefoot restaurant has great casual dining by the water.

Reviewed on Mar 31, 2026

Opens in a new windowParadise Point Resort & Spa
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N San Diego CA
The price is CA $162 per night from Apr 13 to Apr 14
CA $162
CA $186 total
Apr 13 - Apr 14
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the helpful staff ...
Love the pool

Reviewed on Mar 31, 2026

Opens in a new windowHandlery Hotel
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
Fully refundableReserve now, pay when you stay
The price is CA $211 per night from Apr 2 to Apr 3
CA $211
CA $293 total
Apr 2 - Apr 3
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
No breakfast, the tv no work, we pay extra for parking,

Reviewed on Mar 31, 2026

Opens in a new windowWyndham San Diego Bayside
Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
Fully refundableReserve now, pay when you stay
The price is CA $174 per night from Apr 4 to Apr 5
CA $174
CA $261 total
Apr 4 - Apr 5
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
Overall, our family of 4’s stay was pleasant. The only thing was there was what I believe to be sewage gas backup coming out of the shower drain (room 440). Had the same experience at the Sheraton Toronto Airport, something about these older Sheraton hotels…

Reviewed on Mar 31, 2026

Opens in a new windowSheraton San Diego Resort
Days Inn by Wyndham San Diego Hotel Circle

Days Inn by Wyndham San Diego Hotel Circle

3 out of 5
543 Hotel Circle S San Diego CA
Fully refundableReserve now, pay when you stay
The price is CA $149 per night from Apr 26 to Apr 27
CA $149
CA $171 total
Apr 26 - Apr 27
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, a fitness center, and parking (surcharge). Our guests praise the helpful staff and ...
Heated pool. Convenient location. Kitchenettes. Perfect for families

Reviewed on Mar 31, 2026

Opens in a new windowDays Inn by Wyndham San Diego Hotel Circle
Best Western Seven Seas

Best Western Seven Seas

3 out of 5
411 Hotel Circle South San Diego CA
Fully refundableReserve now, pay when you stay
The price is CA $114 per night from Apr 5 to Apr 6
CA $114
CA $131 total
Apr 5 - Apr 6
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, free parking, and 2 hot tubs. Our guests praise the pool and the restaurant in our ...
clean room

Reviewed on Mar 30, 2026

Opens in a new windowBest Western Seven Seas
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Recent Otay Mesa hotel reviews by fellow wanderers

The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

1 out of 5
Posted 2 hours ago
Travelocity Verified Review
"Parking is almost $40 per night. No WiFi(system down). Room dirty. Still waiting to get my deposit back after almost a week. Room is tiny."
A verified traveller stayed at The DEXTRO Little Italy, BW Premier Collection
The DEXTRO Little Italy, BW Premier Collection

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