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Hotels near Otay Mesa

Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
Fully refundableReserve now, pay when you stay
The price is CA $200 per night from Nov 22 to Nov 23
CA $200
CA $282 total
Nov 22 - Nov 23
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
"We were charged a 30$ “destination fee” that I didn’t notice at checkout. Location was perfect for checking into a cruise the next morning, perfect for using the trolly to old town or little italy, and a beautiful harbor stroll in the morning though."

Reviewed on Nov 15, 2026

Opens in a new windowWyndham San Diego Bayside
The Alcala Hotel Mission Valley/Seaworld

The Alcala Hotel Mission Valley/Seaworld

2.5 out of 5
San Diego CA
Fully refundableReserve now, pay when you stay
The price is CA $102 per night from Dec 14 to Dec 15
CA $102
CA $118 total
Dec 14 - Dec 15
includes taxes & fees
Book a stay at this golf hotel in San Diego. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the helpful staff and the clean rooms in ...
"Parking lot wasn’t not too great and the walls super thin, could hear everything."

Reviewed on Nov 15, 2026

Opens in a new windowThe Alcala Hotel Mission Valley/Seaworld
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

2.5 out of 5
2296 Niels Bohr Ct San Diego CA
Fully refundable
The price is CA $186 per night from Dec 13 to Dec 14
CA $186
CA $211 total
Dec 13 - Dec 14
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Opens in a new windowHoliday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
Fully refundableReserve now, pay when you stay
The price is CA $233 per night from Nov 22 to Nov 23
CA $233
CA $339 total
Nov 22 - Nov 23
includes taxes & fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ...
Opens in a new windowHard Rock Hotel San Diego
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N San Diego CA
Fully refundableReserve now, pay when you stay
The price is CA $129 per night from Dec 1 to Dec 2
CA $129
CA $148 total
Dec 1 - Dec 2
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the helpful staff ...
Opens in a new windowHandlery Hotel
Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd San Diego CA
Fully refundableReserve now, pay when you stay
The price is CA $263 per night from Dec 16 to Dec 17
CA $263
CA $378 total
Dec 16 - Dec 17
includes taxes & fees
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
Opens in a new windowParadise Point Resort & Spa
Best Western Seven Seas

Best Western Seven Seas

3 out of 5
411 Hotel Circle South San Diego CA
Fully refundableReserve now, pay when you stay
The price is CA $121 per night from Nov 16 to Nov 17
CA $121
CA $139 total
Nov 16 - Nov 17
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, free parking, and 2 hot tubs. Our guests praise the pool and the restaurant in our ...
Opens in a new windowBest Western Seven Seas
Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
Fully refundableReserve now, pay when you stay
The price is CA $166 per night from Nov 22 to Nov 23
CA $166
CA $262 total
Nov 22 - Nov 23
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
Opens in a new windowSheraton San Diego Resort
Days Inn by Wyndham San Diego Hotel Circle

Days Inn by Wyndham San Diego Hotel Circle

3 out of 5
543 Hotel Circle S San Diego CA
Fully refundableReserve now, pay when you stay
The price is CA $120 per night from Nov 29 to Nov 30
CA $120
CA $138 total
Nov 29 - Nov 30
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, a fitness center, and parking (surcharge). Our guests praise the helpful staff and ...
Opens in a new windowDays Inn by Wyndham San Diego Hotel Circle
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

About Otay Mesa Hotels

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Recent Otay Mesa hotel reviews by fellow wanderers

The Alcala Hotel Mission Valley/Seaworld

The Alcala Hotel Mission Valley/Seaworld

4 out of 5
Posted 12 hours ago
Travelocity Verified Review
"Very good breakfast and clean room."
A verified traveller stayed at The Alcala Hotel Mission Valley/Seaworld
The Alcala Hotel Mission Valley/Seaworld

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