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Hotels near Otay Mesa

Marriott Marquis San Diego Marina

333 W Harbor Dr, San Diego, CA

Free cancellation

24.49 km from Otay Mesa

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Book a stay at this spa hotel in San Diego. Enjoy 2 outdoor pools, a full-service spa, and 5 restaurants. Our guests praise the pool and the helpful staff in our reviews. Popular attractions Seaport Village and Petco Park are located nearby.

Manchester Grand Hyatt San Diego

1 Market Pl, San Diego, CA

Free cancellation

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24.77 km from Otay Mesa

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Stay at this 4-star eco-certified hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the bar in our reviews. Popular attractions Seaport Village and USS Midway Museum are located nearby.

Kings Inn San Diego

1333 Hotel Cir S, San Diego, CA

Free cancellation

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29.1 km from Otay Mesa

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Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the breakfast and the pool in our reviews. Popular attractions San Diego Zoo and Balboa Park are located nearby.

The Dana on Mission Bay

1710 W Mission Bay Dr, San Diego, CA

Free cancellation

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33.74 km from Otay Mesa

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Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in our reviews. Popular attractions Mission Beach and Mission Bay are located nearby.

Handlery Hotel

950 Hotel Cir N, San Diego, CA

Free cancellation

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29.09 km from Otay Mesa

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Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the bar in our reviews. Popular attractions San Diego Zoo and Balboa Park are located nearby.

Pool

Hot tub

DoubleTree by Hilton Hotel San Diego - Mission Valley

7450 Hazard Center Dr, San Diego, CA

Free cancellation

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29.15 km from Otay Mesa

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Book a stay at this business-friendly hotel in San Diego. Enjoy breakfast (surcharge), room service, and a 24-hour fitness center. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions San Diego Zoo and Balboa Park are located nearby.

Comfort Inn Sea World Area

3880 Greenwood St, San Diego, CA

Free cancellation

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30.77 km from Otay Mesa

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Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Mission Bay and Mission Beach are located nearby.

Embassy Suites by Hilton San Diego Bay Downtown

601 Pacific Hwy, San Diego, CA

Free cancellation

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25.03 km from Otay Mesa

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Book a stay at this family-friendly hotel in San Diego. Enjoy free breakfast, room service, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Seaport Village and USS Midway Museum are located nearby.

Wyndham Garden San Diego Near SeaWorld

3737 Sports Arena Blvd, San Diego, CA

Free cancellation

Reserve now, pay when you stay

31.36 km from Otay Mesa

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Stay at this 3-star business-friendly hotel in San Diego. Enjoy free WiFi, parking (surcharge), and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Mission Bay and Mission Beach are located nearby.

Wyndham San Diego Bayside

1355 N Harbor Drive, San Diego, CA

Free cancellation

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25.71 km from Otay Mesa

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Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant in our reviews. Popular attractions Port of San Diego and USS Midway Museum are located nearby.

Pool

Free airport shuttle

Sheraton San Diego Resort

1380 Harbor Island Dr, San Diego, CA

Free cancellation

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28.09 km from Otay Mesa

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Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant in our reviews. Popular attractions Port of San Diego and USS Midway Museum are located nearby.

Lafayette Hotel & Club

2223 El Cajon Blvd, San Diego, CA

Free cancellation

Reserve now, pay when you stay

26.78 km from Otay Mesa

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Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 3 bars/lounges. Our guests praise the helpful staff in our reviews. Popular attractions San Diego Zoo and Balboa Park are located nearby.

Pool

Pet-friendly

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Otay Mesa hotels essential information

Accommodation	4,573 hotels
Lowest Price
Highest Price
Popular hotels	Marriott Marquis San Diego Marina, Manchester Grand Hyatt San Diego, Kings Inn San Diego, The Dana on Mission Bay, Handlery Hotel, DoubleTree by Hilton Hotel San Diego - Mission Valley, Comfort Inn Sea World Area, Embassy Suites by Hilton San Diego Bay Downtown, Wyndham Garden San Diego Near SeaWorld, Wyndham San Diego Bayside, Sheraton San Diego Resort, Lafayette Hotel & Club