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Featured Buffalo 4 Star hotels

The Delavan Hotel & Spa

The Delavan Hotel & Spa

4 out of 5
6461 Transit Road Bowmansville NY
Fully refundableReserve now, pay when you stay
The price is CA $139 per night from Apr 12 to Apr 13
CA $139
CA $158 total
Apr 12 - Apr 13
includes taxes & fees
Book a stay at this business-friendly hotel in Bowmansville. Enjoy free WiFi, free parking, and 2 restaurants. Our guests praise the helpful staff and the clean ...
9/10 Wonderful! (999 reviews)
Yes

Reviewed on Apr 6, 2026

Opens in a new windowThe Delavan Hotel & Spa
The Mansion On Delaware Ave

The Mansion On Delaware Ave

4 out of 5
414 Delaware Ave Buffalo NY
Fully refundableReserve now, pay when you stay
The price is CA $284 per night from Apr 9 to Apr 10
CA $284
CA $326 total
Apr 9 - Apr 10
includes taxes & fees
Book a stay at this business-friendly hotel in Buffalo. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the bar in our ...
9.4/10 Exceptional! (1,004 reviews)
Love the room I got, on a silent spot!

Reviewed on Apr 7, 2026

Opens in a new windowThe Mansion On Delaware Ave
DoubleTree by Hilton Hotel Buffalo - Amherst

DoubleTree by Hilton Hotel Buffalo - Amherst

4 out of 5
10 Flint Rd Buffalo NY
Fully refundableReserve now, pay when you stay
The price is CA $158 per night from Apr 26 to Apr 27
CA $158
CA $180 total
Apr 26 - Apr 27
includes taxes & fees
Book a stay at this business-friendly hotel in Buffalo. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the ...
7.8/10 Good! (1,002 reviews)
Great hotel and room

Reviewed on Apr 5, 2026

Opens in a new windowDoubleTree by Hilton Hotel Buffalo - Amherst
Reikart House, Buffalo, a Tribute Portfolio Hotel

Reikart House, Buffalo, a Tribute Portfolio Hotel

4 out of 5
5000 Main Street Buffalo NY
Fully refundableReserve now, pay when you stay
The price is CA $276 per night from Apr 10 to Apr 11
CA $276
CA $314 total
Apr 10 - Apr 11
includes taxes & fees
Book a stay at this business-friendly hotel in Buffalo. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in our ...
9.6/10 Exceptional! (701 reviews)
Room was very clean and comfortable

Reviewed on Mar 30, 2026

Opens in a new windowReikart House, Buffalo, a Tribute Portfolio Hotel
The Mosey Buffalo Williamsville, Tapestry Collection by Hilton

The Mosey Buffalo Williamsville, Tapestry Collection by Hilton

4 out of 5
5195 Main Street Buffalo NY
Fully refundableReserve now, pay when you stay
The price is CA $200 per night from Apr 26 to Apr 27
CA $200
CA $227 total
Apr 26 - Apr 27
includes taxes & fees
Book a stay at this spa hotel in Buffalo. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff and the clean rooms in our ...
9.4/10 Exceptional! (1,001 reviews)
extremely clean rooms and hotel grounds were impeccable

Reviewed on Apr 2, 2026

Opens in a new windowThe Mosey Buffalo Williamsville, Tapestry Collection by Hilton
The Westin Buffalo

The Westin Buffalo

4 out of 5
250 Delaware Ave Buffalo NY
The price is CA $399 per night from May 3 to May 4
CA $399
CA $466 total
May 3 - May 4
includes taxes & fees
Book a stay at this business-friendly hotel in Buffalo. Enjoy breakfast (surcharge), room service, and a fitness center. Our guests praise the helpful staff ...
9.2/10 Wonderful! (415 reviews)
Exceptional experience.

Reviewed on Mar 23, 2026

Opens in a new windowThe Westin Buffalo
Buffalo Harmony House

Buffalo Harmony House

4.5 out of 5
70 Wadsworth Street Buffalo NY
The price is CA $343 per night from Apr 26 to Apr 27
CA $343
CA $400 total
Apr 26 - Apr 27
includes taxes & fees
Book a stay at this luxury B&B in Buffalo. Enjoy free breakfast, free WiFi, and daily housekeeping. Our guests praise the breakfast in our reviews. Popular attractions ...
10/10 Exceptional! (49 reviews)
Thank you so much for your gracious hospitality. The renovations that you have done on the house are great. Look forward to staying again.

Reviewed on Mar 5, 2026

Opens in a new windowBuffalo Harmony House
Lofts on Pearl Trademark Collection by Wyndham

Lofts on Pearl Trademark Collection by Wyndham

4 out of 5
92 Pearl Street Buffalo NY
Stay at this apartment in Buffalo. Enjoy free WiFi, 2 restaurants, and a 24-hour front desk. Popular attractions KeyBank Center and Walden Galleria Mall are ...
9.2/10 Wonderful! (520 reviews)
Great location
Very easy and fast check in. Property manager managed to find ways to connect with me after unable to contact Expedia that our original property is closed on Sunday and we have to move to another property. The info provided was accurate. The location is really good. Close to city and easy access ...

Reviewed on Oct 14, 2020

Opens in a new windowLofts on Pearl Trademark Collection by Wyndham
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

4 Star Hotels Buffalo

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Buffalo 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Buffalo will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Buffalo, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

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