Find and compare 4 Star hotels in San Mateo

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

This weekend
Next weekend

Featured San Mateo 4 Star hotels

Hyatt Regency San Francisco

Hyatt Regency San Francisco

4 out of 5
5 Embarcadero Center San Francisco CA
Fully refundableReserve now, pay when you stay
The price is CA $254 per night from Jul 12 to Jul 13
CA $254
CA $365 total
Jul 12 - Jul 13
includes taxes & fees
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and ...
9.4/10 Exceptional! (2,324 reviews)
"Location, location, location!"

Reviewed on Jun 30, 2026

Opens in a new windowHyatt Regency San Francisco
Hilton San Francisco Financial District

Hilton San Francisco Financial District

4 out of 5
750 Kearny St San Francisco CA
Fully refundableReserve now, pay when you stay
The price is CA $168 per night from Jul 12 to Jul 13
CA $168
CA $198 total
Jul 12 - Jul 13
includes taxes & fees
Book a stay at this business-friendly hotel in San Francisco. Enjoy breakfast (surcharge), a fitness center, and WiFi (surcharge). Our guests praise the helpful ...
8.8/10 Excellent! (2,954 reviews)
"Nice place, helpful staff, good price for the area"

Reviewed on Jun 30, 2026

Opens in a new windowHilton San Francisco Financial District
Club Quarters Hotel in San Francisco

Club Quarters Hotel in San Francisco

4 out of 5
424 Clay St San Francisco CA
Fully refundableReserve now, pay when you stay
The price is CA $200 per night from Jul 31 to Aug 1
CA $200
CA $235 total
Jul 31 - Aug 1
includes taxes & fees
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and ...
9/10 Wonderful! (3,279 reviews)
"Great staff and excellent location but let down by the hotel decor and fittings looking tired. I would stay here again though."

Reviewed on Jun 30, 2026

Opens in a new windowClub Quarters Hotel in San Francisco
Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

4 out of 5
2500 Mason St San Francisco CA
Fully refundableReserve now, pay when you stay
The price is CA $185 per night from Jul 5 to Jul 6
CA $185
CA $276 total
Jul 5 - Jul 6
includes taxes & fees
Book a stay at this business-friendly hotel in San Francisco. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast ...
9/10 Wonderful! (7,525 reviews)
"Everything was very clean and the staff was very nice. Breakfast was top notch!"

Reviewed on Jun 30, 2026

Opens in a new windowHotel Riu Plaza Fisherman's Wharf
Hyatt Regency San Francisco Downtown SOMA

Hyatt Regency San Francisco Downtown SOMA

4 out of 5
50 3rd St San Francisco CA
Fully refundableReserve now, pay when you stay
The price is CA $240 per night from Jul 31 to Aug 1
CA $240
CA $339 total
Jul 31 - Aug 1
includes taxes & fees
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
9.4/10 Exceptional! (1,266 reviews)
"The vale parking it is a bit expensive"

Reviewed on Jun 30, 2026

Opens in a new windowHyatt Regency San Francisco Downtown SOMA
Grand Hyatt at SFO

Grand Hyatt at SFO

4 out of 5
55 S McDonnell Rd San Francisco CA
The price is CA $349 per night from Jul 2 to Jul 3
CA $349
CA $390 total
Jul 2 - Jul 3
includes taxes & fees
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Our guests praise the restaurant ...
9.8/10 Exceptional! (1,644 reviews)
"Booked as stay here as we had the first flight out at 5:15am. The property was beautiful, convenient, luxurious and made the early far less stressful for our family. The on site SFO tram access, 24/7 market, comfortable beds, amenities were great. If I have another early am out at this location, ..."

Reviewed on Jun 30, 2026

Opens in a new windowGrand Hyatt at SFO
Hyatt Regency San Francisco Airport

Hyatt Regency San Francisco Airport

4 out of 5
1333 Bayshore Hwy Burlingame CA
Fully refundableReserve now, pay when you stay
The price is CA $192 per night from Jul 3 to Jul 4
CA $192
CA $258 total
Jul 3 - Jul 4
includes taxes & fees
Book a stay at this family-friendly hotel in Burlingame. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the restaurant ...
9/10 Wonderful! (1,400 reviews)
"Room was great, pool was great, very helpful staff"

Reviewed on Jun 30, 2026

Opens in a new windowHyatt Regency San Francisco Airport
Hilton San Francisco Union Square

Hilton San Francisco Union Square

4 out of 5
333 O'Farrell St. San Francisco CA
Fully refundableReserve now, pay when you stay
The price is CA $216 per night from Jul 31 to Aug 1
CA $216
CA $254 total
Jul 31 - Aug 1
includes taxes & fees
Book a stay at this business-friendly hotel in San Francisco. Enjoy 2 bars/lounges, breakfast (surcharge), and a 24-hour health club. Our guests praise the helpful ...
8.6/10 Excellent! (1,387 reviews)
"Clean room awesome fitness center"

Reviewed on Jun 30, 2026

Opens in a new windowHilton San Francisco Union Square
San Francisco Marriott Marquis

San Francisco Marriott Marquis

4 out of 5
780 Mission Street San Francisco CA
Fully refundableReserve now, pay when you stay
The price is CA $226 per night from Jul 31 to Aug 1
CA $226
CA $330 total
Jul 31 - Aug 1
includes taxes & fees
Book a stay at this business-friendly hotel in San Francisco. Enjoy 2 restaurants, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the ...
8.8/10 Excellent! (1,225 reviews)
"I didn’t eat"

Reviewed on Jun 30, 2026

Opens in a new windowSan Francisco Marriott Marquis
Hilton San Francisco Airport Bayfront

Hilton San Francisco Airport Bayfront

4 out of 5
600 Airport Boulevard Burlingame CA
Fully refundableReserve now, pay when you stay
The price is CA $163 per night from Jul 5 to Jul 6
CA $163
CA $186 total
Jul 5 - Jul 6
includes taxes & fees
Book a stay at this business-friendly hotel in Burlingame. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the breakfast ...
8.6/10 Excellent! (3,013 reviews)
"Room is clean but a little bit old"

Reviewed on Jun 30, 2026

Opens in a new windowHilton San Francisco Airport Bayfront
Don't see what you're looking for?
See all available properties in San Mateo
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

4 Star Hotels San Mateo

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in San Mateo 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in San Mateo will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in San Mateo, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent San Mateo hotel reviews by fellow wanderers

Explore More Ways to Travel with Travelocity